My system drive got full the other day, and today I noticed aw-server-rust wasn't responding to API requests (but was happily serving the web UI).
After a while I realized what may have caused it, and indeed found in the logs:
thread '<unnamed>' panicked at 'Failed to commit datastore transaction! database or disk is full', aw-datastore/src/worker.rs:182:29
So, when the disk gets full, the DB worker thread panics, and future DB requests will just fail to respond (since the worker is dead).