diff --git a/src/components/Search/SearchMultipleSelectionPicker.tsx b/src/components/Search/SearchMultipleSelectionPicker.tsx
index a58e4510c0fd..bd91307b0c82 100644
--- a/src/components/Search/SearchMultipleSelectionPicker.tsx
+++ b/src/components/Search/SearchMultipleSelectionPicker.tsx
@@ -115,6 +115,7 @@ function SearchMultipleSelectionPicker<T extends string | string[]>({
             sections={sections}
             ListItem={MultiSelectListItem}
             initiallyFocusedItemKey={initiallyFocusedKey}
+            shouldUpdateFocusedIndex
             shouldClearInputOnSelect={false}
             shouldShowTextInput={shouldShowTextInput}
             textInputOptions={textInputOptions}
diff --git a/src/components/SelectionList/SelectionListWithSections/BaseSelectionListWithSections.tsx b/src/components/SelectionList/SelectionListWithSections/BaseSelectionListWithSections.tsx
index 4f6bb2a1f020..f162b2d5e52a 100644
--- a/src/components/SelectionList/SelectionListWithSections/BaseSelectionListWithSections.tsx
+++ b/src/components/SelectionList/SelectionListWithSections/BaseSelectionListWithSections.tsx
@@ -170,6 +170,9 @@ function BaseSelectionListWithSections<TItem extends ListItem>({
             }
         }
         if (shouldUpdateFocusedIndex && typeof indexToFocus === 'number') {
+            if (indexToFocus !== focusedIndex) {
+                suppressNextFocusScrollRef.current = true;
+            }
             setFocusedIndex(indexToFocus);
         }
         onSelectRow(item);
@@ -268,6 +271,10 @@ function BaseSelectionListWithSections<TItem extends ListItem>({
         setFocusedIndex,
     });
 
+    const suppressNextFocusScroll = () => {
+        suppressNextFocusScrollRef.current = true;
+    };
+
     useSearchFocusSync({
         searchValue: textInputOptions?.value,
         data: flattenedData,
@@ -277,7 +284,9 @@ function BaseSelectionListWithSections<TItem extends ListItem>({
         shouldUpdateFocusedIndex,
         scrollToIndex,
         setFocusedIndex,
+        focusedIndex,
         firstFocusableIndex,
+        suppressNextFocusScroll,
     });
 
     const textInputComponent = () => {
diff --git a/src/components/SelectionList/hooks/useSearchFocusSync.ts b/src/components/SelectionList/hooks/useSearchFocusSync.ts
index 9a7fe7aefe4a..3aaf46412b44 100644
--- a/src/components/SelectionList/hooks/useSearchFocusSync.ts
+++ b/src/components/SelectionList/hooks/useSearchFocusSync.ts
@@ -27,8 +27,14 @@ type UseSearchFocusSyncParams<TItem extends ListItem, TData = TItem> = {
     /** Function to set the focused index */
     setFocusedIndex: (index: number) => void;
 
+    /** The current focused index — needed to avoid arming scroll suppression when the index won't actually change */
+    focusedIndex?: number;
+
     /** The first focusable index in the list (useful when index 0 is a header). Defaults to 0. */
     firstFocusableIndex?: number;
+
+    /** Optional callback to suppress the scroll that onFocusedIndexChange would otherwise trigger when setFocusedIndex is called */
+    suppressNextFocusScroll?: () => void;
 };
 
 /**
@@ -47,7 +53,9 @@ function useSearchFocusSync<TItem extends ListItem, TData = TItem>({
     shouldUpdateFocusedIndex,
     scrollToIndex,
     setFocusedIndex,
+    focusedIndex,
     firstFocusableIndex = 0,
+    suppressNextFocusScroll,
 }: UseSearchFocusSyncParams<TItem, TData>) {
     const prevSearchValue = usePrevious(searchValue);
     const prevSelectedOptionsCount = usePrevious(selectedOptionsCount);
@@ -72,6 +80,9 @@ function useSearchFocusSync<TItem extends ListItem, TData = TItem>({
 
             if (foundSelectedItemIndex !== -1 && !canSelectMultiple) {
                 scrollToIndex(foundSelectedItemIndex, false);
+                if (foundSelectedItemIndex !== focusedIndex) {
+                    suppressNextFocusScroll?.();
+                }
                 setFocusedIndex(foundSelectedItemIndex);
                 return;
             }
@@ -91,6 +102,9 @@ function useSearchFocusSync<TItem extends ListItem, TData = TItem>({
 
         // Scroll to top of list and focus on first focusable item (not header)
         scrollToIndex(0, false);
+        if (firstFocusableIndex !== focusedIndex) {
+            suppressNextFocusScroll?.();
+        }
         setFocusedIndex(firstFocusableIndex);
     }, [
         canSelectMultiple,
@@ -104,7 +118,9 @@ function useSearchFocusSync<TItem extends ListItem, TData = TItem>({
         shouldUpdateFocusedIndex,
         searchValue,
         isItemSelected,
+        focusedIndex,
         firstFocusableIndex,
+        suppressNextFocusScroll,
     ]);
 }