As the title says, the 2-lane, 5-lane and 6-lane highways are affected by snowfall. Other highways, including the built-in ones, are not affected. This problem is especially annoying when the highways are not reachable by snow plows, because they are only connected to outside connections.
4-lane highways are not affected by this problem. From what I saw in the source code (which isn't the easiest to understand :P), I think this might be because the 4-lane highway is based on the 3-lane highway, whereas the others are based on ONEWAY_2L (2-lane highway) and ONEWAY_6L (5-lane and 6-lane highways). Obviously, these one-way roads are designed to be affected by snow.
Also, I should note that these highways are NOT affected by road maintenance, so in that aspect they are compliant with the other highways.