diff --git a/.changes/next-release/bugfix-HTTP-97508.json b/.changes/next-release/bugfix-HTTP-97508.json
new file mode 100644
index 000000000000..ce54cd210fa2
--- /dev/null
+++ b/.changes/next-release/bugfix-HTTP-97508.json
@@ -0,0 +1,5 @@
+{
+  "type": "bugfix",
+  "category": "HTTP",
+  "description": "Fixed an issue where reused connections could return a cached response status, dropping response headers."
+}
diff --git a/awscli/botocore/awsrequest.py b/awscli/botocore/awsrequest.py
index f7a18a3d8ab6..759befc02430 100644
--- a/awscli/botocore/awsrequest.py
+++ b/awscli/botocore/awsrequest.py
@@ -88,11 +88,11 @@ def request(self, method, url, body=None, headers=None, *args, **kwargs):
         if headers is None:
             headers = {}
         self._response_received = False
+        self.response_class = self._original_response_cls
         if headers.get('Expect', b'') == b'100-continue':
             self._expect_header_set = True
         else:
             self._expect_header_set = False
-            self.response_class = self._original_response_cls
         rval = super().request(method, url, body, headers, *args, **kwargs)
         self._expect_header_set = False
         return rval
diff --git a/tests/unit/botocore/test_awsrequest.py b/tests/unit/botocore/test_awsrequest.py
index b3c5ae5b59a7..b0ac22f314ba 100644
--- a/tests/unit/botocore/test_awsrequest.py
+++ b/tests/unit/botocore/test_awsrequest.py
@@ -598,6 +598,52 @@ def test_state_reset_on_connection_close(self):
             # current response.,
             self.assertEqual(response.status, 200)
 
+    def test_early_final_response_does_not_corrupt_next_response(self):
+        # Request A is a 0-byte upload with Expect: 100-continue. Because the
+        # body is empty, the server skips "100 Continue" and returns the final
+        # 200 immediately. _handle_expect_response caches that status via
+        # response_class -> the connection is now poisoned.
+        #
+        # Request B reuses the SAME connection WITHOUT close().
+        # request() should reset response_class
+
+        with mock.patch('urllib3.util.wait_for_read') as wait_mock:
+            wait_mock.return_value = True
+            conn = AWSHTTPConnection('s3.amazonaws.com', 443)
+
+            # Request A: 0-byte upload -> early final 200 (no 100 Continue).
+            # Content-Length: 0 keeps the connection open (not auto-closed), so
+            # the poisoned response_class persists for the next request.
+            conn.sock = FakeSocket(
+                b'HTTP/1.1 200 OK\r\nContent-Length: 0\r\n\r\n'
+            )
+            conn.request(
+                'PUT', '/empty-object', b'', {'Expect': b'100-continue'}
+            )
+            response_a = conn.getresponse()
+            self.assertEqual(response_a.status, 200)
+            response_a.read()  # drain so the connection can be reused
+
+            # Request B: a normal non-empty upload reusing the connection
+            # (no close()). The server does the normal 100 -> 200 with an ETag.
+            conn.sock = FakeSocket(
+                b'HTTP/1.1 100 (Continue)\r\n\r\n'
+                b'HTTP/1.1 200 OK\r\n'
+                b'ETag: "test-etag"\r\n'
+                b'Content-Length: 0\r\n'
+                b'\r\n'
+            )
+            conn.request(
+                'PUT', '/real-object', b'body', {'Expect': b'100-continue'}
+            )
+            response_b = conn.getresponse()
+
+            # Status is 200 either way (the leaked cached status is also 200),
+            # so this is only a sanity check. It should have a proper parsed
+            # Etag
+            self.assertEqual(response_b.status, 200)
+            self.assertEqual(response_b.headers.get('ETag'), '"test-etag"')
+
 
 class TestAWSHTTPConnectionPool(unittest.TestCase):
     def test_global_urllib3_pool_is_unchanged(self):