diff --git a/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTEnhancedScrollView.mm b/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTEnhancedScrollView.mm
index 1b02e8b2d396..b3481c1b98b4 100644
--- a/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTEnhancedScrollView.mm
+++ b/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTEnhancedScrollView.mm
@@ -102,6 +102,20 @@ - (void)setContentOffset:(CGPoint)contentOffset
       RCTSanitizeNaNValue(contentOffset.y, @"scrollView.contentOffset.y"));
 }
 
+- (void)setCenterContent:(BOOL)centerContent
+{
+  if (_centerContent != centerContent) {
+    _centerContent = centerContent;
+    [self centerContentIfNeeded];
+  }
+}
+
+- (void)setContentSize:(CGSize)contentSize
+{
+  [super setContentSize:contentSize];
+  [self centerContentIfNeeded];
+}
+
 - (void)setFrame:(CGRect)frame
 {
   [super setFrame:frame];
diff --git a/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm b/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
index eafd0bfee920..fd9f0eedd02a 100644
--- a/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
+++ b/packages/react-native/React/Fabric/Mounting/ComponentViews/ScrollView/RCTScrollViewComponentView.mm
@@ -396,11 +396,19 @@ - (void)updateProps:(const Props::Shared &)props oldProps:(const Props::Shared &
 
   MAP_SCROLL_VIEW_PROP(zoomScale);
 
-  if (oldScrollViewProps.contentInset != newScrollViewProps.contentInset) {
-    _scrollView.contentInset = RCTUIEdgeInsetsFromEdgeInsets(newScrollViewProps.contentInset);
+  RCTEnhancedScrollView *scrollView = (RCTEnhancedScrollView *)_scrollView;
+
+  // When disabling centerContent, reset inset to prop value
+  // (enabling is handled automatically by the setCenterContent: setter)
+  if (oldScrollViewProps.centerContent && !newScrollViewProps.centerContent) {
+    scrollView.contentInset = RCTUIEdgeInsetsFromEdgeInsets(newScrollViewProps.contentInset);
   }
 
-  RCTEnhancedScrollView *scrollView = (RCTEnhancedScrollView *)_scrollView;
+  // Only apply contentInset from props if centerContent is disabled
+  // When centerContent is enabled, the inset is calculated by centerContentIfNeeded
+  if (oldScrollViewProps.contentInset != newScrollViewProps.contentInset && !newScrollViewProps.centerContent) {
+    _scrollView.contentInset = RCTUIEdgeInsetsFromEdgeInsets(newScrollViewProps.contentInset);
+  }
   if (oldScrollViewProps.contentOffset != newScrollViewProps.contentOffset) {
     _scrollView.contentOffset = RCTCGPointFromPoint(newScrollViewProps.contentOffset);
   }