diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 544bb7900008..d686f8293158 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -930,7 +930,9 @@ jobs:
         with:
           node-version-file: 'dev-packages/e2e-tests/test-applications/${{ matrix.test-application }}/package.json'
       - name: Set up Bun
-        if: contains(fromJSON('["node-exports-test-app","nextjs-16-bun", "elysia-bun"]'), matrix.test-application)
+        if:
+          contains(fromJSON('["node-exports-test-app","nextjs-16-bun", "elysia-bun", "hono-4"]'),
+          matrix.test-application)
         uses: oven-sh/setup-bun@v2
       - name: Set up AWS SAM
         if: matrix.test-application == 'aws-serverless'
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/.gitignore b/dev-packages/e2e-tests/test-applications/hono-4/.gitignore
new file mode 100644
index 000000000000..534f51704346
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/.gitignore
@@ -0,0 +1,36 @@
+# prod
+dist/
+
+# dev
+.yarn/
+!.yarn/releases
+.vscode/*
+!.vscode/launch.json
+!.vscode/*.code-snippets
+.idea/workspace.xml
+.idea/usage.statistics.xml
+.idea/shelf
+
+# deps
+node_modules/
+.wrangler
+
+# env
+.env
+.env.production
+.dev.vars
+
+# logs
+logs/
+*.log
+npm-debug.log*
+yarn-debug.log*
+yarn-error.log*
+pnpm-debug.log*
+lerna-debug.log*
+
+# test
+test-results
+
+# misc
+.DS_Store
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/.npmrc b/dev-packages/e2e-tests/test-applications/hono-4/.npmrc
new file mode 100644
index 000000000000..070f80f05092
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/.npmrc
@@ -0,0 +1,2 @@
+@sentry:registry=http://127.0.0.1:4873
+@sentry-internal:registry=http://127.0.0.1:4873
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/package.json b/dev-packages/e2e-tests/test-applications/hono-4/package.json
new file mode 100644
index 000000000000..117555f7241f
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/package.json
@@ -0,0 +1,43 @@
+{
+  "name": "hono-4",
+  "type": "module",
+  "version": "0.0.0",
+  "private": true,
+  "scripts": {
+    "dev:cf": "wrangler dev --var \"E2E_TEST_DSN:$E2E_TEST_DSN\" --log-level=$(test $CI && echo 'none' || echo 'log')",
+    "dev:node": "node --import tsx/esm --import @sentry/node/preload src/entry.node.ts",
+    "dev:bun": "bun src/entry.bun.ts",
+    "build": "wrangler deploy --dry-run",
+    "test:build": "pnpm install && pnpm build",
+    "test:assert": "TEST_ENV=production playwright test"
+  },
+  "dependencies": {
+    "@sentry/hono": "latest || *",
+    "@sentry/node": "latest || *",
+    "@hono/node-server": "^1.19.10",
+    "hono": "^4.12.14"
+  },
+  "devDependencies": {
+    "@playwright/test": "~1.56.0",
+    "@cloudflare/workers-types": "^4.20240725.0",
+    "@sentry-internal/test-utils": "link:../../../test-utils",
+    "tsx": "^4.20.3",
+    "typescript": "^5.5.2",
+    "wrangler": "^4.61.0"
+  },
+  "volta": {
+    "extends": "../../package.json"
+  },
+  "sentryTest": {
+    "variants": [
+      {
+        "assert-command": "RUNTIME=node pnpm test:assert",
+        "label": "hono-4 (node)"
+      },
+      {
+        "assert-command": "RUNTIME=bun pnpm test:assert",
+        "label": "hono-4 (bun)"
+      }
+    ]
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/playwright.config.ts b/dev-packages/e2e-tests/test-applications/hono-4/playwright.config.ts
new file mode 100644
index 000000000000..74a21e10a349
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/playwright.config.ts
@@ -0,0 +1,32 @@
+import { getPlaywrightConfig } from '@sentry-internal/test-utils';
+
+type Runtime = 'cloudflare' | 'node' | 'bun';
+
+const RUNTIME = (process.env.RUNTIME || 'cloudflare') as Runtime;
+
+const testEnv = process.env.TEST_ENV;
+
+if (!testEnv) {
+  throw new Error('No test env defined');
+}
+
+const APP_PORT = 38787;
+
+const startCommands: Record<Runtime, string> = {
+  cloudflare: `pnpm dev:cf --port ${APP_PORT}`,
+  node: `pnpm dev:node`,
+  bun: `pnpm dev:bun`,
+};
+
+const config = getPlaywrightConfig(
+  {
+    startCommand: startCommands[RUNTIME],
+    port: APP_PORT,
+  },
+  {
+    workers: '100%',
+    retries: 0,
+  },
+);
+
+export default config;
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/src/entry.bun.ts b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.bun.ts
new file mode 100644
index 000000000000..2a27d1adb8a9
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.bun.ts
@@ -0,0 +1,24 @@
+import { Hono } from 'hono';
+import { sentry } from '@sentry/hono/bun';
+import { addRoutes } from './routes';
+
+const app = new Hono<{ Bindings: { E2E_TEST_DSN: string } }>();
+
+app.use(
+  // @ts-expect-error - Env is not yet in type
+  sentry(app, {
+    dsn: process.env.E2E_TEST_DSN,
+    environment: 'qa',
+    tracesSampleRate: 1.0,
+    tunnel: 'http://localhost:3031/',
+  }),
+);
+
+addRoutes(app);
+
+const port = Number(process.env.PORT || 38787);
+
+export default {
+  port,
+  fetch: app.fetch,
+};
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/src/entry.cloudflare.ts b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.cloudflare.ts
new file mode 100644
index 000000000000..e348dde56226
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.cloudflare.ts
@@ -0,0 +1,18 @@
+import { Hono } from 'hono';
+import { sentry } from '@sentry/hono/cloudflare';
+import { addRoutes } from './routes';
+
+const app = new Hono<{ Bindings: { E2E_TEST_DSN: string } }>();
+
+app.use(
+  sentry(app, env => ({
+    dsn: env.E2E_TEST_DSN,
+    environment: 'qa',
+    tracesSampleRate: 1.0,
+    tunnel: 'http://localhost:3031/',
+  })),
+);
+
+addRoutes(app);
+
+export default app;
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/src/entry.node.ts b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.node.ts
new file mode 100644
index 000000000000..eb2c669c6806
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/src/entry.node.ts
@@ -0,0 +1,24 @@
+import { Hono } from 'hono';
+import { sentry } from '@sentry/hono/node';
+import { serve } from '@hono/node-server';
+import { addRoutes } from './routes';
+
+const app = new Hono<{ Bindings: { E2E_TEST_DSN: string } }>();
+
+app.use(
+  // @ts-expect-error - Env is not yet in type
+  sentry(app, {
+    dsn: process.env.E2E_TEST_DSN,
+    environment: 'qa',
+    tracesSampleRate: 1.0,
+    tunnel: 'http://localhost:3031/',
+  }),
+);
+
+addRoutes(app);
+
+const port = Number(process.env.PORT || 38787);
+
+serve({ fetch: app.fetch, port }, () => {
+  console.log(`Hono (Node) listening on port ${port}`);
+});
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/src/routes.ts b/dev-packages/e2e-tests/test-applications/hono-4/src/routes.ts
new file mode 100644
index 000000000000..fbb273c7c425
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/src/routes.ts
@@ -0,0 +1,24 @@
+import type { Hono } from 'hono';
+import { HTTPException } from 'hono/http-exception';
+
+export function addRoutes(app: Hono<{ Bindings: { E2E_TEST_DSN: string } }>): void {
+  app.get('/', c => {
+    return c.text('Hello Hono!');
+  });
+
+  app.get('/test-param/:paramId', c => {
+    return c.json({ paramId: c.req.param('paramId') });
+  });
+
+  app.get('/error/:cause', c => {
+    throw new Error('This is a test error for Sentry!', {
+      cause: c.req.param('cause'),
+    });
+  });
+
+  app.get('/http-exception/:code', c => {
+    // oxlint-disable-next-line typescript/no-explicit-any
+    const code = Number(c.req.param('code')) as any;
+    throw new HTTPException(code, { message: `HTTPException ${code}` });
+  });
+}
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/start-event-proxy.mjs b/dev-packages/e2e-tests/test-applications/hono-4/start-event-proxy.mjs
new file mode 100644
index 000000000000..cd6f91b3455d
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/start-event-proxy.mjs
@@ -0,0 +1,6 @@
+import { startEventProxyServer } from '@sentry-internal/test-utils';
+
+startEventProxyServer({
+  port: 3031,
+  proxyServerName: 'hono-4',
+});
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/tests/errors.test.ts b/dev-packages/e2e-tests/test-applications/hono-4/tests/errors.test.ts
new file mode 100644
index 000000000000..e85958e8328b
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/tests/errors.test.ts
@@ -0,0 +1,54 @@
+import { expect, test } from '@playwright/test';
+import { waitForError } from '@sentry-internal/test-utils';
+
+const APP_NAME = 'hono-4';
+
+test('captures error thrown in route handler', async ({ baseURL }) => {
+  const errorWaiter = waitForError(APP_NAME, event => {
+    return event.exception?.values?.[0]?.value === 'This is a test error for Sentry!';
+  });
+
+  const response = await fetch(`${baseURL}/error/test-cause`);
+  expect(response.status).toBe(500);
+
+  const event = await errorWaiter;
+  expect(event.exception?.values?.[0]?.value).toBe('This is a test error for Sentry!');
+});
+
+test('captures HTTPException with 502 status', async ({ baseURL }) => {
+  const errorWaiter = waitForError(APP_NAME, event => {
+    return event.exception?.values?.[0]?.value === 'HTTPException 502';
+  });
+
+  const response = await fetch(`${baseURL}/http-exception/502`);
+  expect(response.status).toBe(502);
+
+  const event = await errorWaiter;
+  expect(event.exception?.values?.[0]?.value).toBe('HTTPException 502');
+});
+
+// TODO: 401 and 404 HTTPExceptions should not be captured by Sentry by default,
+// but currently they are. Fix the filtering and update these tests accordingly.
+test('captures HTTPException with 401 status', async ({ baseURL }) => {
+  const errorWaiter = waitForError(APP_NAME, event => {
+    return event.exception?.values?.[0]?.value === 'HTTPException 401';
+  });
+
+  const response = await fetch(`${baseURL}/http-exception/401`);
+  expect(response.status).toBe(401);
+
+  const event = await errorWaiter;
+  expect(event.exception?.values?.[0]?.value).toBe('HTTPException 401');
+});
+
+test('captures HTTPException with 404 status', async ({ baseURL }) => {
+  const errorWaiter = waitForError(APP_NAME, event => {
+    return event.exception?.values?.[0]?.value === 'HTTPException 404';
+  });
+
+  const response = await fetch(`${baseURL}/http-exception/404`);
+  expect(response.status).toBe(404);
+
+  const event = await errorWaiter;
+  expect(event.exception?.values?.[0]?.value).toBe('HTTPException 404');
+});
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/tests/tracing.test.ts b/dev-packages/e2e-tests/test-applications/hono-4/tests/tracing.test.ts
new file mode 100644
index 000000000000..58c73c6a8369
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/tests/tracing.test.ts
@@ -0,0 +1,41 @@
+import { expect, test } from '@playwright/test';
+import { waitForTransaction } from '@sentry-internal/test-utils';
+
+const APP_NAME = 'hono-4';
+
+test('sends a transaction for the index route', async ({ baseURL }) => {
+  const transactionWaiter = waitForTransaction(APP_NAME, event => {
+    return event.transaction === 'GET /';
+  });
+
+  const response = await fetch(`${baseURL}/`);
+  expect(response.status).toBe(200);
+
+  const transaction = await transactionWaiter;
+  expect(transaction.contexts?.trace?.op).toBe('http.server');
+});
+
+test('sends a transaction for a parameterized route', async ({ baseURL }) => {
+  const transactionWaiter = waitForTransaction(APP_NAME, event => {
+    return event.transaction === 'GET /test-param/:paramId';
+  });
+
+  const response = await fetch(`${baseURL}/test-param/123`);
+  expect(response.status).toBe(200);
+
+  const transaction = await transactionWaiter;
+  expect(transaction.contexts?.trace?.op).toBe('http.server');
+  expect(transaction.transaction).toBe('GET /test-param/:paramId');
+});
+
+test('sends a transaction for a route that throws', async ({ baseURL }) => {
+  const transactionWaiter = waitForTransaction(APP_NAME, event => {
+    return event.transaction === 'GET /error/:cause';
+  });
+
+  await fetch(`${baseURL}/error/test-cause`);
+
+  const transaction = await transactionWaiter;
+  expect(transaction.contexts?.trace?.op).toBe('http.server');
+  expect(transaction.contexts?.trace?.status).toBe('internal_error');
+});
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/tsconfig.json b/dev-packages/e2e-tests/test-applications/hono-4/tsconfig.json
new file mode 100644
index 000000000000..3c4abeff44d6
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/tsconfig.json
@@ -0,0 +1,13 @@
+{
+  "compilerOptions": {
+    "target": "ESNext",
+    "module": "ESNext",
+    "moduleResolution": "Bundler",
+    "strict": true,
+    "skipLibCheck": true,
+    "lib": ["ESNext"],
+    "jsx": "react-jsx",
+    "jsxImportSource": "hono/jsx",
+    "types": ["@cloudflare/workers-types"]
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/hono-4/wrangler.jsonc b/dev-packages/e2e-tests/test-applications/hono-4/wrangler.jsonc
new file mode 100644
index 000000000000..d4344dfa198a
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/hono-4/wrangler.jsonc
@@ -0,0 +1,7 @@
+{
+  "$schema": "node_modules/wrangler/config-schema.json",
+  "name": "hono-4",
+  "main": "src/entry.cloudflare.ts",
+  "compatibility_date": "2026-04-20",
+  "compatibility_flags": ["nodejs_compat"],
+}