diff --git a/.github/downstream.d/aws-dynamodb-encryption-python.sh b/.github/downstream.d/aws-dynamodb-encryption-python.sh
deleted file mode 100755
index 401313bd90aa..000000000000
--- a/.github/downstream.d/aws-dynamodb-encryption-python.sh
+++ /dev/null
@@ -1,16 +0,0 @@
-#!/bin/bash -ex
-
-case "${1}" in
-    install)
-        cd aws-dynamodb-encryption-python
-        uv pip install -e .
-        uv pip install -r test/upstream-requirements-py311.txt
-        ;;
-    run)
-        cd aws-dynamodb-encryption-python
-        pytest -n auto test/ -m "local and not slow and not veryslow and not nope"
-        ;;
-    *)
-        exit 1
-        ;;
-esac
diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 960ca7de2874..d641d86e389e 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -408,11 +408,6 @@ jobs:
             # Latest commit on the aws-encryption-sdk-python master branch, as of May 29, 2026.
             REF: 61040db041104dfd950d1541039ad996dbe895be
             PATH: aws-encryption-sdk-python
-          - DOWNSTREAM: aws-dynamodb-encryption-python
-            REPO: awslabs/aws-dynamodb-encryption-python
-            # Latest commit on the aws-dynamodb-encryption-python master branch, as of Apr 29, 2026.
-            REF: fbdf52978e99f06b1b513b4be33d826c5ac5ada1
-            PATH: aws-dynamodb-encryption-python
           - DOWNSTREAM: certbot
             REPO: certbot/certbot
             # Latest commit on the certbot main branch, as of Jun 02, 2026.
@@ -459,7 +454,7 @@ jobs:
       - name: Setup python
         uses: actions/setup-python@a309ff8b426b58ec0e2a45f0f869d46889d02405 # v6.2.0
         with:
-          python-version: '3.12'
+          python-version: '3.13'
           cache: pip
           cache-dependency-path: ci-constraints-requirements.txt
         timeout-minutes: 3