diff --git a/AUTHORS b/AUTHORS
index e2fad5e8364..d97fca162af 100644
--- a/AUTHORS
+++ b/AUTHORS
@@ -206,6 +206,7 @@ Guido Wesdorp
 Guoqiang Zhang
 Hamza Mobeen
 Harald Armin Massa
+Hardik Kaurani
 Harshna
 Henk-Jaap Wagenaar
 Henry Schreiner
diff --git a/changelog/15099.bugfix.rst b/changelog/15099.bugfix.rst
new file mode 100644
index 00000000000..1fc71bf29f2
--- /dev/null
+++ b/changelog/15099.bugfix.rst
@@ -0,0 +1 @@
+``monkeypatch.setattr()`` now correctly restores attributes on objects with a custom ``__setattr__``.
diff --git a/src/_pytest/monkeypatch.py b/src/_pytest/monkeypatch.py
index 453c6728ee2..ca35b15b05d 100644
--- a/src/_pytest/monkeypatch.py
+++ b/src/_pytest/monkeypatch.py
@@ -258,13 +258,17 @@ def setattr(
         # avoid class descriptors like staticmethod/classmethod
         if inspect.isclass(target):
             oldval = target.__dict__.get(name, NOTSET)
-        elif not _is_data_descriptor(type(target), name):
-            # With no data descriptor in the way, the `setattr()` below writes
-            # into the instance `__dict__`, so `undo()` has to restore that
-            # `__dict__` entry. Assigning an inherited `oldval` back onto the
-            # instance would instead leave behind a new entry shadowing the
-            # class attribute, which permanently freezes descriptors that
-            # resolve dynamically (#10644).
+        elif type(target).__setattr__ is object.__setattr__ and not _is_data_descriptor(
+            type(target), name
+        ):
+            # With no data descriptor in the way and default `object.__setattr__`,
+            # the `setattr()` below writes into the instance `__dict__`, so
+            # `undo()` has to restore that `__dict__` entry. Assigning an
+            # inherited `oldval` back onto the instance would instead leave behind
+            # a new entry shadowing the class attribute, which permanently freezes
+            # descriptors that resolve dynamically (#10644).
+            # When `__setattr__` is overridden, attribute setting is routed through
+            # custom machinery which may store values elsewhere (#15099).
             target_dict = getattr(target, "__dict__", None)
             if isinstance(target_dict, Mapping):
                 oldval = target_dict.get(name, NOTSET)
@@ -434,7 +438,10 @@ def undo(self) -> None:
             if value is not NOTSET:
                 setattr(obj, name, value)
             else:
-                delattr(obj, name)
+                try:
+                    delattr(obj, name)
+                except AttributeError:
+                    pass
         self._setattr[:] = []
         for dictionary, key, value in reversed(self._setitem):
             if value is NOTSET:
diff --git a/testing/test_monkeypatch.py b/testing/test_monkeypatch.py
index 0d07783b05b..3e5587373c6 100644
--- a/testing/test_monkeypatch.py
+++ b/testing/test_monkeypatch.py
@@ -607,6 +607,98 @@ def __init__(self) -> None:
     assert obj.x == 1
 
 
+def test_undo_custom_setattr_without_delattr() -> None:
+    """An object with custom __setattr__ but NO __delattr__ should not crash on undo.
+
+    See #15099 maintainer review. Since the object doesn't support deletion,
+    undo() catches AttributeError and tolerates it, though it cannot physically remove the attribute.
+    """
+
+    class ConfigNoDel:
+        _data: dict[str, object]
+
+        def __init__(self) -> None:
+            object.__setattr__(self, "_data", {})
+
+        def __getattr__(self, name: str) -> object:
+            try:
+                return self._data[name]
+            except KeyError:
+                raise AttributeError(name) from None
+
+        def __setattr__(self, name: str, value: object) -> None:
+            self._data[name] = value
+
+    cfg = ConfigNoDel()
+    monkeypatch = MonkeyPatch()
+
+    # Attribute initially absent
+    assert not hasattr(cfg, "brand_new")
+
+    # Set missing attribute with raising=False
+    monkeypatch.setattr(cfg, "brand_new", True, raising=False)
+    assert cfg.brand_new is True
+
+    # Undo should not raise AttributeError, even though delattr(cfg, "brand_new") fails
+    monkeypatch.undo()
+
+    # Note: We CANNOT assert not hasattr(cfg, "brand_new") here, because without
+    # a custom __delattr__, monkeypatch has no generic way to remove the attribute
+    # from the custom storage (_data). The tolerance avoids the teardown crash.
+    assert cfg.brand_new is True
+
+
+def test_undo_custom_setattr_with_delattr() -> None:
+    """An object with custom __setattr__ and __delattr__ must restore its old value on undo."""
+
+    class Config:
+        """Stores attributes in a private dict instead of __dict__."""
+
+        _data: dict[str, object]
+
+        def __init__(self) -> None:
+            object.__setattr__(self, "_data", {"debug": False})
+
+        def __getattr__(self, name: str) -> object:
+            try:
+                return self._data[name]
+            except KeyError:
+                raise AttributeError(name) from None
+
+        def __setattr__(self, name: str, value: object) -> None:
+            self._data[name] = value
+
+        def __delattr__(self, name: str) -> None:
+            try:
+                del self._data[name]
+            except KeyError:
+                raise AttributeError(name) from None
+
+    cfg = Config()
+    monkeypatch = MonkeyPatch()
+
+    with pytest.raises(AttributeError, match="has no attribute 'nonexistent'"):
+        monkeypatch.setattr(cfg, "nonexistent", True)
+
+    # Test setting a missing attribute with raising=False
+    monkeypatch.setattr(cfg, "nonexistent", True, raising=False)
+    assert getattr(cfg, "nonexistent") is True
+
+    # Test setting an existing attribute
+    monkeypatch.setattr(cfg, "debug", True)
+    assert getattr(cfg, "debug") is True
+
+    monkeypatch.undo()
+    assert getattr(cfg, "debug") is False
+    assert not hasattr(cfg, "nonexistent")
+
+    # Test that undoing an already-deleted attribute doesn't raise (the AttributeError tolerance)
+    monkeypatch.setattr(cfg, "brand_new", True, raising=False)
+    delattr(cfg, "brand_new")
+    monkeypatch.undo()
+    assert not hasattr(cfg, "brand_new")
+
+
 def test_issue1338_name_resolving() -> None:
     pytest.importorskip("requests")
     monkeypatch = MonkeyPatch()