diff --git a/Lib/profiling/sampling/binary_collector.py b/Lib/profiling/sampling/binary_collector.py
index afbbc829269067..cdbb76b878b1d1 100644
--- a/Lib/profiling/sampling/binary_collector.py
+++ b/Lib/profiling/sampling/binary_collector.py
@@ -1,5 +1,6 @@
 """Thin Python wrapper around C binary writer for profiling data."""
 
+import sys
 import time
 
 import _remote_debugging
@@ -61,6 +62,7 @@ def __init__(self, filename, sample_interval_usec, *, skip_idle=False,
         self.filename = filename
         self.sample_interval_usec = sample_interval_usec
         self.skip_idle = skip_idle
+        self.running = True
 
         compression_type = _resolve_compression(compression)
         start_time_us = int(time.monotonic() * 1_000_000)
@@ -81,7 +83,13 @@ def collect(self, stack_frames, timestamp_us=None):
         """
         if timestamp_us is None:
             timestamp_us = int(time.monotonic() * 1_000_000)
-        self._writer.write_sample(stack_frames, timestamp_us)
+        try:
+            self._writer.write_sample(stack_frames, timestamp_us)
+        except OverflowError as e:
+            self.running = False
+            print(f"Warning: {e}; stopping early and keeping the data "
+                  "collected so far.",
+                  file=sys.stderr)
 
     def collect_failed_sample(self):
         """Record a failed sample attempt (no-op for binary format)."""
diff --git a/Lib/test/test_profiling/test_sampling_profiler/test_binary_format.py b/Lib/test/test_profiling/test_sampling_profiler/test_binary_format.py
index 56dac2cf86a764..ae4a87b832fd79 100644
--- a/Lib/test/test_profiling/test_sampling_profiler/test_binary_format.py
+++ b/Lib/test/test_profiling/test_sampling_profiler/test_binary_format.py
@@ -9,6 +9,8 @@
 import unittest
 from collections import defaultdict
 
+from test.support import captured_stderr
+
 try:
     import _remote_debugging
     from _remote_debugging import (
@@ -994,6 +996,83 @@ def test_writer_total_samples_after_close_returns_zero(self):
         w.close()
         self.assertEqual(w.total_samples, 0)
 
+    def test_binary_collector_stops_gracefully_on_overflow(self):
+        """OverflowError from the writer stops collection via the running
+        protocol instead of propagating and corrupting the file.
+        See gh-151292."""
+        with tempfile.NamedTemporaryFile(suffix=".bin", delete=False) as f:
+            filename = f.name
+        self.temp_files.append(filename)
+
+        collector = BinaryCollector(filename, 1000, compression="none")
+        self.assertTrue(collector.running)
+
+        sample = [
+            make_interpreter(0, [make_thread(1, [make_frame("a.py", 1, "f")])])
+        ]
+
+        # Collect real samples first, then hit the limit.
+        for i in range(3):
+            collector.collect(sample, timestamp_us=(i + 1) * 1000)
+        self.assertTrue(collector.running)
+
+        real_writer = collector._writer
+
+        class _OverflowingWriter:
+            def write_sample(self, stack_frames, timestamp_us):
+                raise OverflowError("too many samples for binary format")
+
+        collector._writer = _OverflowingWriter()
+        with captured_stderr() as stderr:
+            collector.collect(sample, timestamp_us=4000)
+
+        self.assertFalse(collector.running)
+        self.assertIn("too many samples", stderr.getvalue())
+
+        # The real writer can still be finalized into a valid file that
+        # keeps the samples collected before the limit was hit.
+        collector._writer = real_writer
+        collector.export(None)
+
+        with open(filename, "rb") as f:
+            header = f.read(32)
+        magic, version = struct.unpack_from("=II", header, 0)
+        self.assertEqual(magic, 0x54414348)  # "TACH"
+        self.assertEqual(version, 1)
+        (sample_count,) = struct.unpack_from("=I", header, 28)
+        self.assertEqual(sample_count, 3)
+
+        reader_collector = RawCollector()
+        with BinaryReader(filename) as reader:
+            self.assertEqual(reader.replay_samples(reader_collector), 3)
+
+    def test_interpreter_id_overflow_rejected(self):
+        """An interpreter_id wider than u32 raises OverflowError before any
+        writer state is mutated: subsequent valid samples are still accepted
+        and finalize produces a readable file."""
+        with tempfile.NamedTemporaryFile(suffix=".bin", delete=False) as f:
+            filename = f.name
+        self.temp_files.append(filename)
+
+        good = [
+            make_interpreter(0, [make_thread(1, [make_frame("a.py", 1, "f")])])
+        ]
+        bad = [
+            make_interpreter(2**32, [make_thread(1, [make_frame("a.py", 1, "f")])])
+        ]
+
+        writer = _remote_debugging.BinaryWriter(filename, 1000, 0, compression=0)
+        writer.write_sample(good, 1000)
+        with self.assertRaises(OverflowError):
+            writer.write_sample(bad, 2000)
+        writer.write_sample(good, 3000)
+        writer.finalize()
+        self.assertEqual(writer.total_samples, 2)
+
+        reader_collector = RawCollector()
+        with BinaryReader(filename) as reader:
+            self.assertEqual(reader.replay_samples(reader_collector), 2)
+
 
 class TestBinaryFormatValidation(BinaryFormatTestBase):
     """Tests for malformed binary files."""
diff --git a/Misc/NEWS.d/next/Library/2026-07-02-15-26-51.gh-issue-151292.nmnQlp.rst b/Misc/NEWS.d/next/Library/2026-07-02-15-26-51.gh-issue-151292.nmnQlp.rst
new file mode 100644
index 00000000000000..eb3bda128bb256
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-07-02-15-26-51.gh-issue-151292.nmnQlp.rst
@@ -0,0 +1,3 @@
+Fix ``profiling.sampling --binary`` leaving unreadable profile files when
+the ``_remote_debugging`` binary writer raises :exc:`OverflowError`. Patch
+by Maurycy Pawłowski-Wieroński.