diff --git a/Doc/library/tkinter.rst b/Doc/library/tkinter.rst
index ca034fcdc09b439..fb97c12e48059d1 100644
--- a/Doc/library/tkinter.rst
+++ b/Doc/library/tkinter.rst
@@ -1894,6 +1894,31 @@ Base and mixin classes
 
       .. versionadded:: next
 
+   The following members support assistive technologies such as screen
+   readers.
+   They require Tk 9.1 or newer.
+   Tk automatically exposes the standard widgets to the platform
+   accessibility API;
+   the :attr:`!accessible` attributes allow overriding what is exposed,
+   and the :class:`Accessible` methods allow registering custom widgets.
+   If no assistive technology is active when the application starts,
+   setting the attributes has no effect,
+   reading them returns ``0``,
+   and the methods do nothing (except :meth:`!tk_check_screenreader`).
+
+   .. method:: tk_check_screenreader()
+
+      Return whether a screen reader is currently running.
+
+      .. versionadded:: next
+
+   .. attribute:: accessible
+
+      The accessible attributes of the widget,
+      as an :class:`Accessible` object.
+
+      .. versionadded:: next
+
    The methods with the ``busy_`` prefix manage the busy state of a window,
    which shows a busy cursor and ignores user input.
 
@@ -2323,6 +2348,51 @@ Base and mixin classes
       .. versionadded:: 3.11
 
 
+.. class:: Accessible()
+
+   The accessible attributes of a widget,
+   returned by the :attr:`~Misc.accessible` property of the widget.
+   The attributes are exposed to assistive technologies
+   such as screen readers.
+   Requires Tk 9.1 or newer.
+
+   Setting an attribute overrides what Tk exposes for the widget;
+   reading an attribute that has not been set raises
+   :exc:`~tkinter.TclError`.
+   The supported roles are ``Button``, ``Canvas``, ``Checkbutton``,
+   ``Combobox``, ``Entry``, ``Label``, ``Listbox``, ``Menu``,
+   ``Notebook``, ``Progressbar``, ``Scale``, ``Scrollbar``,
+   ``Spinbox``, ``Table``, ``Text`` and ``Tree``.
+
+   .. versionadded:: next
+
+   .. attribute:: role
+                  name
+                  description
+                  value
+                  state
+                  action
+                  help
+
+      The accessible attributes of the widget.
+
+   .. method:: add_object()
+
+      Register the widget with the platform accessibility API.
+      This is only needed for custom widgets;
+      the standard widgets are registered automatically.
+
+   .. method:: emit_selection_change()
+
+      Notify the platform accessibility API that the selection in the
+      widget has changed.
+
+   .. method:: emit_focus_change()
+
+      Notify the platform accessibility API that the widget has received
+      focus.
+      Not available on macOS.
+
 
 .. class:: Wm()
 
diff --git a/Doc/whatsnew/3.16.rst b/Doc/whatsnew/3.16.rst
index e8c75d2f571061a..d5b01aa57090e34 100644
--- a/Doc/whatsnew/3.16.rst
+++ b/Doc/whatsnew/3.16.rst
@@ -358,6 +358,15 @@ tkinter
   report the user idle time.
   (Contributed by Serhiy Storchaka in :gh:`151881`.)
 
+* Added :mod:`tkinter` support for the Tk 9.1 accessibility API: the
+  :attr:`~tkinter.Misc.accessible` property of widgets returns an
+  :class:`~tkinter.Accessible` object whose attributes are exposed to
+  assistive technologies such as screen readers and whose methods register
+  custom widgets with the platform accessibility API, and the
+  :meth:`~tkinter.Misc.tk_check_screenreader` method reports whether a
+  screen reader is running.
+  (Contributed by Serhiy Storchaka in :gh:`145578`.)
+
 * Added new window-management methods :meth:`~tkinter.Misc.winfo_isdark`
   (dark mode detection), :meth:`~tkinter.Wm.wm_iconbadge` (application icon
   badge) and :meth:`~tkinter.Wm.wm_stackorder` (toplevel stacking order).
diff --git a/Lib/test/test_tkinter/test_misc.py b/Lib/test/test_tkinter/test_misc.py
index 5f75b8d245b3e99..500854ecc3e5c91 100644
--- a/Lib/test/test_tkinter/test_misc.py
+++ b/Lib/test/test_tkinter/test_misc.py
@@ -599,6 +599,42 @@ def test_tk_inactive(self):
         # Resetting the timer returns None and does not raise.
         self.assertIsNone(self.root.tk_inactive(reset=True))
 
+    @requires_tk(9, 1)
+    def test_accessible(self):
+        # Without an active screen reader every "tk accessible" call is
+        # a no-op returning 0, so only test that the calls do not raise
+        # and check the values when a screen reader is active.
+        try:
+            sr = self.root.tk_check_screenreader()
+        except tkinter.TclError:
+            # Tk 9.1a0 or Tk compiled without accessibility support
+            # (e.g. without ATK on X11).
+            self.skipTest('the "tk accessible" command is not supported')
+        self.assertIsInstance(sr, bool)
+        f = tkinter.Frame(self.root)
+        acc = f.accessible
+        self.assertIsInstance(acc, tkinter.Accessible)
+        self.assertIs(f.accessible, acc)
+        if sr:
+            # Reading an attribute that has not been set raises TclError.
+            with self.assertRaises(tkinter.TclError):
+                acc.help
+        for attr in ('name', 'description', 'value', 'state',
+                     'action', 'help'):
+            with self.subTest(attr=attr):
+                setattr(acc, attr, 'spam')
+                result = getattr(acc, attr)
+                if sr:
+                    self.assertEqual(result, 'spam')
+        acc.role = 'Label'
+        result = acc.role
+        if sr:
+            self.assertEqual(result, 'Label')
+        acc.add_object()
+        acc.emit_selection_change()
+        if self.root._windowingsystem != 'aqua':
+            acc.emit_focus_change()
+
     def test_wait_variable(self):
         var = tkinter.StringVar(self.root)
         self.assertEqual(self.root.waitvar, self.root.wait_variable)
diff --git a/Lib/tkinter/__init__.py b/Lib/tkinter/__init__.py
index 83d11a7695ffbe3..06927e7e03f54e9 100644
--- a/Lib/tkinter/__init__.py
+++ b/Lib/tkinter/__init__.py
@@ -818,6 +818,25 @@ def tk_inactive(self, reset=False, *, displayof=0):
         else:
             return self.tk.getint(self.tk.call(args))
 
+    def tk_check_screenreader(self):
+        """Return whether a screen reader is currently running.
+
+        Requires Tk 9.1 or newer."""
+        return self.tk.getboolean(self.tk.call(
+                'tk', 'accessible', 'check_screenreader'))
+
+    @property
+    def accessible(self):
+        """The accessible attributes of the widget, as an Accessible
+        object.
+
+        Requires Tk 9.1 or newer."""
+        try:
+            return self._accessible_object
+        except AttributeError:
+            self._accessible_object = Accessible(self)
+            return self._accessible_object
+
     def wait_variable(self, name):
         """Wait until the variable is modified.
 
@@ -2307,6 +2326,67 @@ def yview_scroll(self, number, what):
         self.tk.call(self._w, 'yview', 'scroll', number, what)
 
 
+def _accessible_attribute(name):
+    """Internal function.  Create an Accessible attribute property."""
+    def getter(self):
+        widget = self._widget
+        return widget.tk.call('tk', 'accessible', 'get_acc_' + name,
+                              widget._w)
+    def setter(self, value):
+        widget = self._widget
+        widget.tk.call('tk', 'accessible', 'set_acc_' + name,
+                       widget._w, value)
+    return property(getter, setter,
+                    doc=f'The accessible {name} of the widget.')
+
+
+class Accessible:
+    """The accessible attributes of a widget.
+
+    Returned by the accessible property of a widget.  The attributes
+    are exposed to assistive technologies such as screen readers.
+    Requires Tk 9.1 or newer.
+
+    If no assistive technology is active when the application starts,
+    setting an attribute has no effect and reading it returns 0.
+    Reading an attribute that has not been set raises TclError.
+    """
+
+    def __init__(self, widget):
+        self._widget = widget
+
+    def __repr__(self):
+        return f'<Accessible object of {self._widget!r}>'
+
+    role = _accessible_attribute('role')
+    name = _accessible_attribute('name')
+    description = _accessible_attribute('description')
+    value = _accessible_attribute('value')
+    state = _accessible_attribute('state')
+    action = _accessible_attribute('action')
+    help = _accessible_attribute('help')
+
+    def add_object(self):
+        """Register the widget with the platform accessibility API."""
+        widget = self._widget
+        widget.tk.call('tk', 'accessible', 'add_acc_object', widget._w)
+
+    def emit_selection_change(self):
+        """Notify the platform accessibility API that the selection
+        in the widget has changed."""
+        widget = self._widget
+        widget.tk.call('tk', 'accessible', 'emit_selection_change',
+                       widget._w)
+
+    def emit_focus_change(self):
+        """Notify the platform accessibility API that the widget has
+        received focus.
+
+        Not available on macOS."""
+        widget = self._widget
+        widget.tk.call('tk', 'accessible', 'emit_focus_change', widget._w)
+
+
 class Wm:
     """Provides functions for the communication with the window manager."""
 
diff --git a/Misc/NEWS.d/next/Library/2026-07-06-14-38-02.gh-issue-145578.aX11yQ.rst b/Misc/NEWS.d/next/Library/2026-07-06-14-38-02.gh-issue-145578.aX11yQ.rst
new file mode 100644
index 000000000000000..d32d6a80238fdd3
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-07-06-14-38-02.gh-issue-145578.aX11yQ.rst
@@ -0,0 +1,7 @@
+Added :mod:`tkinter` support for the Tk 9.1 accessibility API: the
+:attr:`~tkinter.Misc.accessible` property of widgets returns an
+:class:`~tkinter.Accessible` object whose attributes are exposed to
+assistive technologies such as screen readers and whose methods register
+custom widgets with the platform accessibility API, and the
+:meth:`~tkinter.Misc.tk_check_screenreader` method reports whether a
+screen reader is running.