diff --git a/flow-typed/npm/promise_v8.x.x.js b/flow-typed/npm/promise_v8.x.x.js
deleted file mode 100644
index 7358622e3bea..000000000000
--- a/flow-typed/npm/promise_v8.x.x.js
+++ /dev/null
@@ -1,30 +0,0 @@
-/**
- * @flow strict
- * @format
- */
-
-declare module 'promise/setimmediate/es6-extensions' {
-  declare module.exports: typeof Promise;
-}
-
-declare module 'promise/setimmediate/done' {
-  declare module.exports: typeof Promise;
-}
-
-declare module 'promise/setimmediate/finally' {
-  declare module.exports: typeof Promise;
-}
-
-declare module 'promise/setimmediate/rejection-tracking' {
-  declare module.exports: {
-    enable: (
-      options?: ?{
-        whitelist?: ?Array<unknown>,
-        allRejections?: ?boolean,
-        onUnhandled?: ?(number, unknown) => void,
-        onHandled?: ?(number, unknown) => void,
-      },
-    ) => void,
-    disable: () => void,
-  };
-}
diff --git a/packages/react-native/Libraries/Core/polyfillPromise.js b/packages/react-native/Libraries/Core/polyfillPromise.js
index 5bfec271d1c5..a202b3b749e6 100644
--- a/packages/react-native/Libraries/Core/polyfillPromise.js
+++ b/packages/react-native/Libraries/Core/polyfillPromise.js
@@ -10,29 +10,17 @@
 
 'use strict';
 
-const {polyfillGlobal} = require('../Utilities/PolyfillFunctions');
-
 /**
- * Set up Promise. The native Promise implementation throws the following error:
- * ERROR: Event loop not supported.
- *
- * If you don't need these polyfills, don't use InitializeCore; just directly
- * require the modules you need from InitializeCore for setup.
+ * Set up Promise. All supported JS engines provide a spec-compliant native
+ * Promise implementation, so it no longer needs to be polyfilled. In DEV,
+ * enable unhandled rejection tracking where the engine supports it.
  */
 
-// If global.Promise is provided by Hermes, we are confident that it can provide
-// all the methods needed by React Native, so we can directly use it.
-if (global?.HermesInternal?.hasPromise?.()) {
-  const HermesPromise = global.Promise;
-
-  if (__DEV__) {
-    if (typeof HermesPromise !== 'function') {
-      console.error('HermesPromise does not exist');
-    }
-    global.HermesInternal?.enablePromiseRejectionTracker?.(
-      require('../promiseRejectionTrackingOptions').default,
-    );
+if (__DEV__) {
+  if (typeof global.Promise !== 'function') {
+    console.error('Promise does not exist');
   }
-} else {
-  polyfillGlobal('Promise', () => require('../Promise').default);
+  global.HermesInternal?.enablePromiseRejectionTracker?.(
+    require('../promiseRejectionTrackingOptions').default,
+  );
 }
diff --git a/packages/react-native/Libraries/Promise.js b/packages/react-native/Libraries/Promise.js
deleted file mode 100644
index 5184765a0c83..000000000000
--- a/packages/react-native/Libraries/Promise.js
+++ /dev/null
@@ -1,23 +0,0 @@
-/**
- * Copyright (c) Meta Platforms, Inc. and affiliates.
- *
- * This source code is licensed under the MIT license found in the
- * LICENSE file in the root directory of this source tree.
- *
- * @flow strict
- * @format
- */
-
-'use strict';
-
-import Promise from 'promise/setimmediate/es6-extensions';
-
-require('promise/setimmediate/finally');
-
-if (__DEV__) {
-  require('promise/setimmediate/rejection-tracking').enable(
-    require('./promiseRejectionTrackingOptions').default,
-  );
-}
-
-export default Promise;
diff --git a/packages/react-native/Libraries/promiseRejectionTrackingOptions.js b/packages/react-native/Libraries/promiseRejectionTrackingOptions.js
index 95fcf1c093d0..4a7b5ec3b515 100644
--- a/packages/react-native/Libraries/promiseRejectionTrackingOptions.js
+++ b/packages/react-native/Libraries/promiseRejectionTrackingOptions.js
@@ -8,11 +8,16 @@
  * @format
  */
 
-import typeof {enable} from 'promise/setimmediate/rejection-tracking';
-
 import ExceptionsManager from './Core/ExceptionsManager';
 
-const rejectionTrackingOptions: NonNullable<Parameters<enable>[0]> = {
+type RejectionTrackingOptions = {
+  whitelist?: ?Array<unknown>,
+  allRejections?: ?boolean,
+  onUnhandled?: ?(number, unknown) => void,
+  onHandled?: ?(number, unknown) => void,
+};
+
+const rejectionTrackingOptions: RejectionTrackingOptions = {
   allRejections: true,
   onHandled: id => {
     const warning =
diff --git a/packages/react-native/package.json b/packages/react-native/package.json
index 9ba6a5668473..95ccddaf327e 100644
--- a/packages/react-native/package.json
+++ b/packages/react-native/package.json
@@ -169,7 +169,6 @@
     "metro-source-map": "^0.87.0",
     "nullthrows": "^1.1.1",
     "pretty-format": "^29.7.0",
-    "promise": "^8.3.0",
     "react-devtools-core": "^6.1.5",
     "react-refresh": "^0.14.0",
     "regenerator-runtime": "^0.13.2",