diff --git a/packages/reflex-base/news/7189.bugfix.md b/packages/reflex-base/news/7189.bugfix.md
new file mode 100644
index 00000000000..cc1981b127f
--- /dev/null
+++ b/packages/reflex-base/news/7189.bugfix.md
@@ -0,0 +1 @@
+`Annotated[...]` hints now resolve to the type they annotate wherever Reflex inspects a type. A var typed with a pydantic discriminated union — `Annotated[Cat | Dog, Field(discriminator="kind")]` — no longer raises `Unsupported type ... for guess_type.` when read out of a state var, and its attributes resolve through the union as usual.
diff --git a/packages/reflex-base/src/reflex_base/utils/types.py b/packages/reflex-base/src/reflex_base/utils/types.py
index 876f8c85b4a..b7e77c6e55d 100644
--- a/packages/reflex-base/src/reflex_base/utils/types.py
+++ b/packages/reflex-base/src/reflex_base/utils/types.py
@@ -52,6 +52,8 @@
 # Potential GenericAlias types for isinstance checks.
 GenericAliasTypes = (_GenericAlias, GenericAlias, _SpecialGenericAlias)
 
+_AnnotatedAlias = type(typing.Annotated[int, ""])
+
 # Potential Union types for isinstance checks.
 UnionTypes = (Union, types.UnionType)
 
@@ -492,11 +494,24 @@ def _apply_type_params(
         return _substitute_type_params(value, substitution)
 
 
+def _annotated_origin(cls: Any) -> Any:
+    """Get the type that ``Annotated[X, ...]`` annotates.
+
+    Args:
+        cls: The type to inspect.
+
+    Returns:
+        ``X`` for ``Annotated[X, ...]``, else None.
+    """
+    return cls.__origin__ if type(cls) is _AnnotatedAlias else None
+
+
 def resolve_type_alias(cls: GenericType) -> GenericType:
-    """Resolve a TypeAliasType (PEP 695 ``type`` statement) to its underlying value.
+    """Resolve a type alias to its underlying value.
 
-    Handles bare aliases, subscripted generic aliases (``Keys[str]`` for
-    ``type Keys[T] = list[T]``, substituting the type parameters into the
+    Unwraps ``Annotated[X, ...]`` to ``X``, and resolves TypeAliasTypes (PEP 695
+    ``type`` statement): bare aliases, subscripted generic aliases (``Keys[str]``
+    for ``type Keys[T] = list[T]``, substituting the type parameters into the
     alias value), and aliases appearing as members of a union.
 
     Args:
@@ -505,6 +520,12 @@ def resolve_type_alias(cls: GenericType) -> GenericType:
     Returns:
         The resolved type, or the original type if it contains no alias.
     """
+    # ``Annotated`` metadata (a pydantic discriminator, a validator, a unit) is
+    # never part of the type Reflex reasons about, and ``__origin__`` already
+    # flattens nested annotations. Unwrapped before the alias branches so that
+    # ``Annotated[SomeAlias, ...]`` resolves both layers.
+    if (annotated := _annotated_origin(cls)) is not None:
+        return resolve_type_alias(annotated)
     origin = get_origin(cls)
     # The subscripted case is checked first: on Python 3.10 ``types.GenericAlias``
     # proxies ``__class__`` to its origin, so ``Keys[str]`` passes an isinstance
@@ -1318,6 +1339,21 @@ def typehint_issubclass(
     if possible_subclass is NoReturn:
         return True
 
+    # ``Annotated[X, ...]`` compares as ``X``. ``get_origin`` reports ``X``
+    # rather than ``Annotated``, so the comparisons below would otherwise read
+    # the hint as a bare ``X`` carrying the metadata as a type argument.
+    if (
+        _annotated_origin(possible_subclass) is not None
+        or _annotated_origin(possible_superclass) is not None
+    ):
+        return typehint_issubclass(
+            resolve_type_alias(possible_subclass),
+            resolve_type_alias(possible_superclass),
+            treat_mutable_superclasss_as_immutable=treat_mutable_superclasss_as_immutable,
+            treat_literals_as_union_of_types=treat_literals_as_union_of_types,
+            treat_any_as_subtype_of_everything=treat_any_as_subtype_of_everything,
+        )
+
     provided_type_origin = get_origin(possible_subclass)
     accepted_type_origin = get_origin(possible_superclass)
 
diff --git a/tests/units/reflex_base/utils/test_types.py b/tests/units/reflex_base/utils/test_types.py
index b42cb81a204..c70523d51d4 100644
--- a/tests/units/reflex_base/utils/test_types.py
+++ b/tests/units/reflex_base/utils/test_types.py
@@ -5,7 +5,7 @@
 import sys
 import typing
 from collections.abc import Callable
-from typing import Literal, TypeVar
+from typing import Annotated, Literal, TypeVar
 
 import pytest
 from reflex_base.utils.types import (
@@ -196,3 +196,53 @@ def test_typehint_issubclass_resolves_type_alias(alias_cls: type) -> None:
     assert typehint_issubclass(maybe, maybe)
     assert not typehint_issubclass(maybe, str)
     assert typehint_issubclass(str, maybe)
+
+
+@pytest.mark.parametrize("alias_cls", _type_alias_types())
+def test_resolve_type_alias_unwraps_annotated(alias_cls: type) -> None:
+    """``Annotated`` metadata is stripped, including around and inside aliases."""
+    assert resolve_type_alias(Annotated[int, "meta"]) is int
+    assert resolve_type_alias(Annotated[Annotated[int, "a"], "b"]) is int
+    assert resolve_type_alias(Annotated[int | str, "meta"]) == int | str
+    # An alias on either side of the annotation resolves through it.
+    assert resolve_type_alias(Annotated[alias_cls("Name", str), "meta"]) is str
+    assert resolve_type_alias(alias_cls("Meta", Annotated[str, "meta"])) is str
+    # A union member keeps resolving.
+    assert resolve_type_alias(Annotated[int, "meta"] | str) == int | str
+
+
+def test_typehint_issubclass_unwraps_annotated() -> None:
+    """``Annotated`` compares as the type it annotates, on either side."""
+    assert typehint_issubclass(Annotated[int, "meta"], int)
+    assert typehint_issubclass(int, Annotated[int, "meta"])
+    assert typehint_issubclass(Annotated[int, "a"], Annotated[int, "b"])
+    assert not typehint_issubclass(Annotated[str, "meta"], int)
+    # The union member-wise comparison must see a union, not the metadata.
+    assert typehint_issubclass(Annotated[int | str, "meta"], int | str)
+    assert typehint_issubclass(int, Annotated[int | str, "meta"])
+    assert not typehint_issubclass(Annotated[int | str, "meta"], int)
+    assert typehint_issubclass(list[Annotated[int, "meta"]], list[int])
+
+
+def test_annotated_attributes_do_not_unwrap_user_classes() -> None:
+    """User-defined metadata attributes must not identify an Annotated hint."""
+
+    class MetadataType:
+        __metadata__ = ("custom",)
+        __origin__ = int
+
+    assert resolve_type_alias(MetadataType) is MetadataType
+
+
+def test_isinstance_unwraps_annotated() -> None:
+    """``_isinstance`` validates against the annotated type, not the metadata."""
+    assert _isinstance(1, Annotated[int, "meta"], nested=1, treat_var_as_type=False)
+    assert not _isinstance(
+        "x", Annotated[int, "meta"], nested=1, treat_var_as_type=False
+    )
+    assert _isinstance(
+        {"a": 1}, dict[str, Annotated[int, "meta"]], nested=2, treat_var_as_type=False
+    )
+    assert not _isinstance(
+        {"a": "x"}, dict[str, Annotated[int, "meta"]], nested=2, treat_var_as_type=False
+    )
diff --git a/tests/units/vars/test_object.py b/tests/units/vars/test_object.py
index 835bf9fbc72..a1e025ff569 100644
--- a/tests/units/vars/test_object.py
+++ b/tests/units/vars/test_object.py
@@ -1,6 +1,6 @@
 import dataclasses
 from collections.abc import Sequence
-from typing import Any
+from typing import Annotated, Any, Literal
 
 import pytest
 from reflex_base.utils.exceptions import VarAttributeError
@@ -336,3 +336,46 @@ def test_rest_prop_merge_propagates_var_data():
     var_data = merged._get_all_var_data()
     assert var_data is not None
     assert "some-lib" in dict(var_data.imports)
+
+
+def test_annotated_value_type_is_unwrapped() -> None:
+    """An ``Annotated`` value type resolves to the type it annotates.
+
+    A pydantic discriminated union is spelled ``Annotated[A | B, Field(...)]``,
+    so reading one out of a mapping must guess the union rather than choke on
+    the metadata.
+    """
+
+    class GenericColor(pydantic.BaseModel):
+        kind: Literal["generic"] = "generic"
+        name: str = ""
+
+    class BrandedColor(pydantic.BaseModel):
+        kind: Literal["branded"] = "branded"
+        name: str = ""
+        brand: str = ""
+
+    any_color = Annotated[
+        GenericColor | BrandedColor, pydantic.Field(discriminator="kind")
+    ]
+    colors = Var(_js_expr="colors", _var_type=dict[str, any_color]).guess_type()
+    assert isinstance(colors, ObjectVar)
+
+    # A literal key reads as an attribute, a Var key as an item operation.
+    for color in (
+        colors["red"],
+        colors[Var(_js_expr="key", _var_type=str).guess_type()],
+    ):
+        assert isinstance(color, ObjectVar)
+        assert color._var_type == GenericColor | BrandedColor
+        assert color.name._var_type is str
+
+
+def test_annotated_var_type_is_unwrapped() -> None:
+    """``guess_type`` sees through ``Annotated`` on the var's own type."""
+    annotated = Annotated[Base, "metadata"]
+    var = Var(_js_expr="obj", _var_type=annotated).guess_type()
+
+    assert isinstance(var, ObjectVar)
+    assert var._var_type is Base
+    assert var.quantity._var_type is int