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@WayScience

The Way Lab

The Way Lab at CU Anschutz

Welcome to the open-source GitHub organization hosted by The Way Lab.

We are a team of scientists and engineers developing methods and software for analyzing microscopy images of cells. Our mission is to reduce human suffering.

Our website contains complete details of our research projects, team members, and funding: https://www.waysciencelab.com/

Check out a few of our open-source projects!

Select Software

Select Projects

We are leading multidisciplinary scientists in a variety of team-science initiatives.

Pediatric Cancer Cell Morphology Atlas

We are developing a reference Cell Painting data set of pediatric cancer cell lines, and performing several high-throughput, high-content phenotypic drug screens.

3D profiling of Neurofibromatosis Type 1 patient-derived organoids

We are developing a 3D image analysis pipeline to profile patient-derived organoids from neurofibromatosis type 1 (NF1) patients, and we will be performing several high-throughput, high-content phenotypic drug screens.

Finding new therapeutics for cardiac fibrosis

We are identifying fundamental differences between cardiac fibroblasts from patients with and without heart failure, and we are developing a high-throughput, high-content phenotypic drug screen to identify new therapeutics for cardiac fibrosis.

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  1. pediatric_cancer_atlas_profiling pediatric_cancer_atlas_profiling Public

    Image analysis and image-based profiling of pediatic cancer cell lines to extract morphological profiles.

    Jupyter Notebook 7 5

  2. ome-arrow ome-arrow Public

    Using OME specifications with Apache Arrow for fast, queryable, and language agnostic bioimage data.

    Python 8 1

  3. buscar buscar Public

    Single cell hit calling for high-content screens

    Python 9 3

  4. ZedProfiler ZedProfiler Public

    Featurizing high-content 3D microscopy images

    Python 2 3

  5. iceberg-bioimage iceberg-bioimage Public

    A format-agnostic framework for cataloging and querying bioimaging data (Parquet, OME-Zarr, OME-TIFF) with Apache Iceberg

    Python 3 2

  6. CPBS7601 CPBS7601 Public

    Course on computing skills in biomedical informatics

    Jupyter Notebook 5 21

Repositories

Showing 10 of 108 repositories
  • demo-uca-isilon-python Public

    Demonstrating capabilities with the University of Colorado Anschutz (UCA) Isilon storage solution using Python.

    WayScience/demo-uca-isilon-python's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 2 5 0 Updated Oct 9, 2026
  • buscar Public

    Single cell hit calling for high-content screens

    WayScience/buscar's past year of commit activity
    Python 9 BSD-3-Clause 3 7 2 Updated Oct 9, 2026
  • NF1_organoid_profile_analysis Public

    This repo contains analysis code of profiles generated in multiple image-based profiling repos.

    WayScience/NF1_organoid_profile_analysis's past year of commit activity
    Jupyter Notebook 1 BSD-3-Clause 3 5 5 Updated Oct 8, 2026
  • cardiac_fibrosis_rescue_screen_profiling Public

    Image analysis and image-based profiling of a fibrosis drug screen to identify compound hits using a machine learning model.

    WayScience/cardiac_fibrosis_rescue_screen_profiling's past year of commit activity
    Jupyter Notebook 3 CC0-1.0 5 15 0 Updated Oct 8, 2026
  • PRISM_Agent_LITL_experiments Public

    Exploring how to better utilize Lab In The Loop (LITL) data in agentic systems with DSPy. Built with DSPy, this repo provides modular agent tools and academic experiments on PRISM-inspired drug repurposing data to test agentic system improvement under different toolsets.

    WayScience/PRISM_Agent_LITL_experiments's past year of commit activity
    Python 1 BSD-3-Clause 1 0 1 Updated Oct 8, 2026
  • RxRx19a-reanalysis Public

    Single-cell phenotypic reversal in RxRx19a

    WayScience/RxRx19a-reanalysis's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 1 0 1 Updated Oct 7, 2026
  • formascute Public

    🐢 Exploring the structure of software workflow execution through small, reproducible experiments.

    WayScience/formascute's past year of commit activity
    Shell 0 BSD-3-Clause 1 0 1 Updated Oct 6, 2026
  • iceberg-bioimage Public

    A format-agnostic framework for cataloging and querying bioimaging data (Parquet, OME-Zarr, OME-TIFF) with Apache Iceberg

    WayScience/iceberg-bioimage's past year of commit activity
    Python 3 BSD-3-Clause 2 2 0 Updated Oct 5, 2026
  • WayScience/pccma_repo1_screen_image_profiling's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 2 3 1 Updated Oct 5, 2026
  • pediatric_cancer_atlas_profiling Public

    Image analysis and image-based profiling of pediatic cancer cell lines to extract morphological profiles.

    WayScience/pediatric_cancer_atlas_profiling's past year of commit activity
    Jupyter Notebook 7 CC0-1.0 5 3 1 Updated Oct 5, 2026

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