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9 create vignette for design and analysis of tte data - #52
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MThomas91 merged 7 commits intoOct 12, 2026
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Merge branch 'master' into 9-create-vignette-for-design-and-analysis-of-tte-data # Conflicts: # vignettes/refs.bib
bbnkmp
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Oct 5, 2026
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| We use the following candidate set of dose-response models for the mean | ||
| response: an $\text{E}_{\text{max}}$, a sigmoidal $\text{E}_{\text{max}}$, a | ||
| quadratic, an exponential and a linear model. |
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There is no linear model in the code below. So maybe remove the reference to linear model here?
Vignette (vignettes/time_to_event_data.Rmd): - Use own VignetteIndexEntry instead of duplicating the continuous-data one - Set seed as in the binary vignette (fixed RNG kinds); seed 2010 chosen so the simulated trial reproduces the stated MCP-step conclusion - simulate_surv_data(): deterministic allocation via rndDesign(), drop unused shape/scale arguments - powMCT_TTE(): replace internal DoseFinding:::powCalc() with exported powMCT() - eventsMCT_TTE(): use sampSize() bisection; fixes reported power being taken from the last evaluated midpoint instead of the returned event count - sampSizeMCT_TTE(): use sampSize() bisection instead of a custom search - Text and documentation fixes (candidate model list, S/S0 description, helper docs, naming of Cox estimates summary) Package metadata: - DESCRIPTION: add survival to Suggests (used by the vignette) - REFERENCES.bib: correct deng2019 author names, journal field and DOI
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October 12, 2026 15:20
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